Holy s***, or Holy crap- sorry to be crude, but your poop is not holy, unless you are God
Holy cow- there are no cows that are holy, not even a pure white one
Holy moley (however you spell it)- I don't think people want to glorify the moles on their body
Holy Guacamole- Although I am obsessed with this stuff, it is not holy
Are there any others you know of?? Food for thought...